Revisio Graminum Japoniae XIII

Endothelin XIII.

Twenty-five years ago, a groundbreaking paper from Tsukuba University in Japan was published, identifying the sequence of the endothelin gene and peptide (Nature 332, 411-415, 1988). This work opened the way for the discovery of the endothelin receptors and the development of orally active endothelin receptor antagonists (ERAs). Today, ERAs are part of medical therapy of patients around the wor...

Type Xiii Collagen

Genomic clones covering the entire mouse type XIII collagen gene (Col13a1) were isolated, and the complete exon-intron organization was characterized. The gene was found to be about 135 kb in size and to locate in the mouse chromosome 10. Comparison of gene structures and promoter regions between man and mouse indicated high conservation between the two species. In order to understand the biolo...

XIII Gene–Environment Interactions

Most genetic-epidemiological approaches used in the study of the aetiology of individual differences in psychiatric disease in humans assume that the effects of genes and environment are additive. That is, it is assumed that the effect of an environmental risk factor does not depend on the genotype of the individual, or, stated differently, that the expression of the genotype does not depend on...

Hæmatological Technique. Part XIII

Xiii. Xenobiotics in Soil